In the build-up to this game, the Angels have a 3-0 edge over the Dodgers in their 2025 meetings, having swept their rivals in a three-game set at Dodger Stadium earlier in the year (Dodgers vs. Angels Prediction, Odds, Probable Pitchers). Overall, the Angels hold a 78-73 advantage in the all-time regular-season series, a surprising statistic given the Dodgers’ perennial contender status.
The Dodgers (68-50) are coming off a narrow 2-1 series win over the Toronto Blue Jays, though they dropped the finale 5-4. Shohei Ohtani and Freddie Freeman continue to provide offensive firepower, with Ohtani hitting a leadoff homer and Freeman adding a solo shot in the last game. However, the Dodgers have been inconsistent recently, going 5-5 over their last 10 games.
Meanwhile, the Angels (56-62) have struggled, losing four of their last five and seven of their last ten games, including two of three to the Detroit Tigers. In Sunday’s 9-5 loss, Nolan Schanuel and Luis Rengifo each hit two-run homers, but the Angels’ pitching woes persisted, with their bullpen ERA at 4.81—26th in the Majors.
The starting pitching matchup features Yoshinobu Yamamoto (10-7, 2.51 ERA) for the Dodgers and José Soriano (7-9, 4.01 ERA) for the Angels. Yamamoto has been a force on the road, posting a 7-3 record and a stellar 1.63 ERA across 12 away starts. He has never faced the Angels before but comes off a dominant outing against the Rays, throwing 5 2/3 shutout innings. Soriano, on the other hand, is coming off a rough performance, allowing seven earned runs in just four innings against Tampa Bay. His home numbers (1-7, 5.56 ERA) reflect the Angels’ broader pitching struggles. Soriano’s only previous appearance against the Dodgers was a brief relief stint in July 2023.
Betting odds heavily favor the Dodgers, with sportsbooks like FanDuel and BetMGM listing them around -174 to -180 on the moneyline and -1.5 (-110) on the run line. The over/under is set at 8.5 runs, with recent trends suggesting value on the under—Yamamoto has allowed two or fewer earned runs in three of his last four starts, and five of the Dodgers’ last eight games have gone under the total.
From a statistical and betting analysis perspective, the Dodgers are the logical pick. Their offense has heated up since the All-Star break, now ranking seventh in OPS since mid-July. The Angels, conversely, have struggled at the plate and on the mound, making it challenging to keep pace with a deep Dodgers lineup. Prop bettors may want to target Yamamoto’s strikeout total; the Angels have the highest strikeout rate in the majors since July, and Yamamoto has hit seven or more Ks in three of his last four starts.
Prediction: Dodgers 4, Angels 2. The Dodgers look poised to end their losing streak against the Angels, and with Yamamoto on the mound, they are strong favorites to cover the run line and keep the game under the total.