Seahawks Aim to Defeat Cardinals in Crucial Week 4 Showdown

The Seattle Seahawks travel to Glendale to face the Arizona Cardinals at State Farm Stadium tonight in a pivotal Week 4 NFC West clash. Both teams enter the matchup with 2-1 records, looking for an edge in one of the league’s most competitive divisions. Kickoff is set for 5:15 p.m. PT (8:15 p.m. ET), with coverage available on Amazon Prime Video and live updates on ESPN. The Seahawks are slight 1.5-point favorites, per SportsLine, after Arizona opened as the favorite. The over/under is set at 43.5 points. Seattle leads the all-time series 29-22-1 and holds a seven-game winning streak against Arizona, including the last four meetings in Glendale. Seattle comes into the game with momentum following a dominant 44-13 victory over the New Orleans Saints. Quarterback Sam Darnold has been efficient, completing 70.3% of his passes for 663 yards, four touchdowns, and two interceptions through three starts. Running back Kenneth Walker III anchors the rushing attack with 163 yards and three touchdowns, while receiver Jaxon Smith-Njigba is second in the NFL in receiving yards (323). Arizona, meanwhile, suffered a narrow 16-15 loss to the San Francisco 49ers in Week 3. Quarterback Kyler Murray has completed 67.4% of his passes for 542 yards and four touchdowns, adding 107 yards on the ground. Tight end Trey McBride leads the Cardinals with 17 receptions for 182 yards and a touchdown. Arizona’s defense has been strong against the run, allowing just 76.3 rushing yards per game, fourth-best in the league. Media predictions are split. Analysts at Sporting News and The Seattle Times favor the Seahawks by narrow margins, citing Darnold’s form and Seattle’s recent success in Arizona. CBS Sports’ Pete Prisco and Matt Calkins lean toward the Cardinals, noting Kyler Murray’s playmaking and home-field advantage, especially with Seattle’s defense facing injuries. Historically, the Seahawks have excelled on the road, seeking their eighth straight road win. However, Thursday Night Football has been challenging for Seattle, with a 1-5 ATS record in their last six appearances. Arizona’s Kyler Murray is 1-6 ATS in his last seven games against Seattle, but the Cardinals will hope to reverse that trend tonight, especially with Trey McBride set for a larger role following James Conner’s injury. Betting experts highlight several key props: Sam Darnold is expected to surpass 218.5 passing yards, given Arizona’s struggles against opposing quarterbacks, while Seahawks kicker Jason Myers is projected to exceed 6.5 points, as Seattle’s red-zone offense has led to frequent field goal attempts. Injury reports include Seattle’s Zach Charbonnet (questionable, foot) and Arizona’s Paris Johnson Jr. (questionable, knee). Both teams will rely on depth if key players are unavailable. With both clubs at 2-1 and the NFC West race tightening, tonight’s result will have significant playoff implications. The Seahawks aim to extend their winning streak over Arizona, while the Cardinals look to rebound and make a statement at home. For a full breakdown of the rosters, visit the Seahawks 53-Man Roster For The 2025 Season. Live coverage, in-game stats, and highlights are available on ESPN and FOX Sports.