Colts Overcome Odds and Defeat Cardinals 31-27 in Dramatic Comeback

The Indianapolis Colts overcame a depleted defense to secure a 31-27 comeback victory over the Arizona Cardinals on Sunday, October 12, 2025, at Lucas Oil Stadium. Quarterback Daniel Jones threw for two touchdowns and rushed for another, while Jonathan Taylor ran for 123 yards, including the decisive 1-yard touchdown with 4:32 left in the fourth quarter. The Colts improved to 5-1 (4-0 at home), while the Cardinals fell to 2-4 after their fourth consecutive loss. Arizona played without starting quarterback Kyler Murray (foot), turning to Jacoby Brissett, who threw for 320 yards and two touchdowns but could not engineer a late-game comeback. The Cardinals reached the Colts’ 9-yard line with just over a minute remaining, but the Indianapolis defense forced a turnover on downs to seal the win. The game saw both teams trade leads throughout the second half, with neither punting in the final two quarters. Jones finished 22-of-30 for 212 yards, two touchdowns, and one interception, adding a rushing score. Rookie tight end Tyler Warren contributed six catches for 63 yards and a touchdown, while Josh Downs caught his first touchdown of the season. Taylor’s performance marked his 27th career 100-yard rushing game and his seventh touchdown of the year. Indianapolis played without key starters in the secondary, including Charvarius Ward (concussion) and Kenny Moore II (Achilles), but still managed critical defensive stops. Defensive end Kwity Paye recorded two sacks, and Mekhi Blackmon had an interception in his second straight game. Michael Badgley, signed after an injury to regular kicker Spencer Shrader, converted a 45-yard field goal to tie the game in the third quarter. For Arizona, tight end Trey McBride had a season-high eight catches for 72 yards and a touchdown. Receiver Marvin Harrison Jr. left in the second quarter with a concussion, and the Cardinals also lost tight end Travis Vokolek to a neck injury in the first quarter, though reports indicated Vokolek was alert and moving his extremities after being carted off. The Colts’ win marks their sixth straight at home over the past two seasons. Indianapolis will travel to Los Angeles to face the Chargers next week, while the Cardinals return home to host the Green Bay Packers. For more details and in-depth stats, see the full box score on ESPN and game highlights on the NFL official game page.