Buffalo enters the game as a 3.5-point favorite, according to ESPN, with the over/under set at 50 points. Quarterback Josh Allen leads the Bills’ offense, averaging 243.4 passing yards per game, with nine touchdowns and two interceptions so far this season. Running back James Cook III has contributed 450 rushing yards, while tight end Dalton Kincaid tops the team with 287 receiving yards. Linebacker Terrel Bernard leads the defense with 26 tackles and one interception.
Injuries remain a concern for Buffalo, with safety Demar Hamlin and linebacker Matt Milano both ruled out. Dalton Kincaid (oblique) and Curtis Samuel (neck/ribs) are listed as questionable. For Atlanta, wide receiver Darnell Mooney will miss the game due to a hamstring injury.
The Bills’ defense is allowing 145.6 rushing yards per game, which could be tested by Atlanta’s ground attack led by Bijan Robinson. However, Buffalo has performed well against the pass, limiting opposing quarterbacks effectively. The Falcons, meanwhile, boast one of the league’s best defenses through four games, allowing only 244.0 yards per contest.
Historically, the Bills have been strong against NFC opponents, going 6-1 straight up in their last seven such games. The matchup at Mercedes-Benz Stadium is set for 7:15 p.m. ET. For more on the Bills’ schedule, stats, and live updates, visit their official schedule page or check the latest odds and projections on SportsLine.