The game is set for Saturday, October 25, with kickoff at 12 p.m. ET, broadcast on ABC. The matchup showcases Ole Miss’ explosive offense, averaging 37.4 points per game and nearly 500 yards per contest, led by quarterback Trinidad Chambliss. Chambliss has been a dual-threat force, topping the SEC with 9.6 yards per attempt, and working with key playmakers like running back Kewan Lacy and receiver Caden Lee. Under head coach Lane Kiffin, Ole Miss is known for its quick-strike, unpredictable attack, but defensive lapses have been an issue—last week, the Rebels surrendered a late lead and lost 43-35 at Georgia, failing to register a single stop in the fourth quarter.
Oklahoma, under defensive-minded coach Brent Venables, counters with the nation’s top-ranked defense. The Sooners lead the SEC with 28 sacks, thanks in part to R. Mason Thomas and a deep rotation—10 players have recorded at least one sack. Oklahoma’s defense thrives in the red zone, allowing touchdowns on just 36% of opponent trips inside the 20, and has held four of seven opponents to seven points or fewer this season. Quarterback John Mateer, a transfer from Washington State, has brought stability and efficiency, helping the Sooners capitalize on excellent field position and disciplined play.
Analysts view this as a “fire vs. ice” battle between an elite offense and a suffocating defense. Expert predictions are split: Josh Pate and David Pollack expect Oklahoma to win and cover the -5.5 spread, citing the Sooners’ home-field advantage and defensive strength, while Rece Davis sees an upset with Ole Miss prevailing. The consensus is that for Ole Miss to win, its defense must step up to slow the Sooners, while Oklahoma will look to control the game’s tempo and force the Rebels into long drives.
This game also carries historical significance, as Ole Miss and Oklahoma are set to become permanent SEC opponents from 2026–2029. The programs have limited history—Ole Miss won their last meeting and has never lost to Oklahoma—but with high stakes and playoff implications, both teams have everything to play for this Saturday.
For live coverage, stats, and highlights, follow the game on ESPN.